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By definition, clodronate liposome is a drug delivered using liposome (a synthetic lipid that encapsulates other substances for ease of administration into the body). Liposome is manly a medium which carries the highly hydrophilic Clodronate thus facilitating its transport into the target organ. Essentially, the aim of this type of drug administration is to achieve higher macrophage depletion after an intravenous injection of the drug.
The idea behind this drug is mainly to use it as the carrier or Trojan horse to help administer drugs that would not easily reach the target organ in normal cases. Provided the liposome has been ingested and digested by the macrophages (in the spleen for instance), the Clodronate is released into the organ though intracellular activities. The resultant product is the effective bisphosphonates that can then stop the macrophage functions.
Examples of the disease this drug is expected to treat include metastatic carcinomas of the breast, multiple myeloma and osteoporosis. It is also expected to be the best solution for autoimmune hyemolitic anemia, cancers and tumors in general. Significant strides have also been made with the drug during tests as far as inhibition of macrophages activities in therapies such gene and transplantation. Even in the handling of neurological disorders, this drug will be the best.
Since other bisphosphonates are in the market, it is easy to predict the side effects that may be associated with the drug once it is released. There is no need to worry though as these effects are classified as mild. For example, a few patients do report stomach pains, nausea and vomiting. In some rare scenarios, bisphosphonates may have some serious reactions.
Most patients have also reported loss of appetite. However, in the event that this drug will present with serious conditions like hives, skin rashes or even difficult breathing it is advisable that one sees a doctor immediately. Unlike the mild symptoms that would disappear after few days, these may be signs of deep-rooted drug reactions.
Other adverse drug reactions that might be associated with this drug include mouth pain, swelling and unexplainable tiredness or weakness. Moreover, patients who develop skin rashes and hives or severe muscle cramps after taking Clodronate should seek medical attention as a matter of urgency. Since these are just pre-release precautions, one should not be discouraged, as the final product may be a very stable product with lesser side effects.
Some general contraindications are common with most prescription drugs. For instance, you should not take the drug if you are allergic to Clodronates or bisphosphonates. Similarly, expecting or breastfeeding mothers should not use the drug. Patients with kidney problems or using other bisphosphonate drugs should not use the drug too. It is also advisable that you stay from these types of drugs if you have inflammation of the gastro intestines.
The use of clodronate liposome, like any other prescription medicine, should be a strict procedure. You are therefore not allowed to share it with other patients even if you suffer from the same disease. Additionally, you are not to borrow such drugs unless a qualified doctor prescribes them. Finally and yet importantly, you have to take the full dose without skipping if significant progress or complete healing is to be realized.
The idea behind this drug is mainly to use it as the carrier or Trojan horse to help administer drugs that would not easily reach the target organ in normal cases. Provided the liposome has been ingested and digested by the macrophages (in the spleen for instance), the Clodronate is released into the organ though intracellular activities. The resultant product is the effective bisphosphonates that can then stop the macrophage functions.
Examples of the disease this drug is expected to treat include metastatic carcinomas of the breast, multiple myeloma and osteoporosis. It is also expected to be the best solution for autoimmune hyemolitic anemia, cancers and tumors in general. Significant strides have also been made with the drug during tests as far as inhibition of macrophages activities in therapies such gene and transplantation. Even in the handling of neurological disorders, this drug will be the best.
Since other bisphosphonates are in the market, it is easy to predict the side effects that may be associated with the drug once it is released. There is no need to worry though as these effects are classified as mild. For example, a few patients do report stomach pains, nausea and vomiting. In some rare scenarios, bisphosphonates may have some serious reactions.
Most patients have also reported loss of appetite. However, in the event that this drug will present with serious conditions like hives, skin rashes or even difficult breathing it is advisable that one sees a doctor immediately. Unlike the mild symptoms that would disappear after few days, these may be signs of deep-rooted drug reactions.
Other adverse drug reactions that might be associated with this drug include mouth pain, swelling and unexplainable tiredness or weakness. Moreover, patients who develop skin rashes and hives or severe muscle cramps after taking Clodronate should seek medical attention as a matter of urgency. Since these are just pre-release precautions, one should not be discouraged, as the final product may be a very stable product with lesser side effects.
Some general contraindications are common with most prescription drugs. For instance, you should not take the drug if you are allergic to Clodronates or bisphosphonates. Similarly, expecting or breastfeeding mothers should not use the drug. Patients with kidney problems or using other bisphosphonate drugs should not use the drug too. It is also advisable that you stay from these types of drugs if you have inflammation of the gastro intestines.
The use of clodronate liposome, like any other prescription medicine, should be a strict procedure. You are therefore not allowed to share it with other patients even if you suffer from the same disease. Additionally, you are not to borrow such drugs unless a qualified doctor prescribes them. Finally and yet importantly, you have to take the full dose without skipping if significant progress or complete healing is to be realized.
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